Towelie often falsely claims that drugs improve his memory and/or make him smarter. It is implied that marijuana is to Towelie's memory as spinach is to Popeye's strength: whenever Towelie smokes a joint, the Popeye theme song is played, as it is when Popeye eats spinach. This ends in an anticlimax with Towelie forgetting where he is and what he was doing, saying "I have no idea what's going on."
Towelie's major appearances include appearing in a self titled episode based around his origin, and in A Million Little Fibers, a parody where he writes a partly fabricated memoir, which gets him into trouble with his fans. After Kenny's death, the boys go searching for a replacement friend in the episode Professor Chaos. Towelie, a possible candidate, was said to be "Stoned all the time. You can't really depend on him for anything", by the boys. Nonetheless, Towelie makes it to the final round.